abstract：:Platelet phospholipid composition was analyzed before and after extracorporeal removal of low density lipoproteins (LDL) by LDL apheresis in six patients with familial hypercholesterolemia. Elevated levels of total plasma cholesterol and the portion of plasma cholesterol carried by LDL were reduced by 56 and 66% after...

journal_title：Atherosclerosis

authors： Bräutigam R,Bräutigam C,Lorenz R,Richter WO,Engelmann B

更新日期：1997-05-01 00:00:00

abstract：:Intimal proliferation and functional changes involving vascular smooth muscle cells are key events in the development of atherosclerosis, including restenosis after percutaneous transluminal angioplasty. Nonmuscle myosin (NMM) is required for cytokinesis and has been shown in cultures of vascular smooth muscle cells t...

journal_title：Atherosclerosis

authors： Nikol S,Murakami N,Pickering JG,Kearney M,Leclerc G,Höfling B,Isner JM,Weir L

更新日期：1997-04-01 00:00:00

abstract：:Apolipoprotein E phenotypes and fasting lipid and other biochemical parameters were determined in 51 patients with recently diagnosed coronary heart disease (CHD) and 164 control subjects. The age of the participants was 62.5 +/- 6.6 (S.D.) and 63% were male. Forty-eight CHD cases and 51 control subjects were also stu...

journal_title：Atherosclerosis

authors： Dart A,Sherrard B,Simpson H

更新日期：1997-04-01 00:00:00

abstract：:Familial ligand-defective apolipoprotein (apo) B-100 (FDB) is an autosomal codominant disorder which may give rise to hypercholesterolaemia. It is caused by the substitution of glutamine for arginine at codon 3500 of the apo B gene (apo B R3500Q), resulting in decreased binding of low density lipoprotein (LDL) to the ...

journal_title：Atherosclerosis

authors： Wenham PR,Henderson BG,Penney MD,Ashby JP,Rae PW,Walker SW

更新日期：1997-03-21 00:00:00

abstract：:Familial combined hyperlipidemia (FCHL) is one of the most common inherited lipid disorders. Resistance of adipocytes to the effects of acylation stimulating protein (ASP) may contribute to ineffective triglyceride synthesis and thereby prolonged postprandial lipemia and increased fatty acid flux to the liver seen in ...

journal_title：Atherosclerosis

authors： Ylitalo K,Porkka KV,Meri S,Nuotio I,Suurinkeroinen L,Vakkilainen J,Pajukanta P,Viikari JS,Peltonen L,Ehnholm C,Taskinen MR

更新日期：1997-03-21 00:00:00

abstract：:Outgrowth of vascular wall cells from rat aortic tissue explant was studied. In addition to fresh rat serum (3%), the complete culture medium contained either low density lipoprotein (LDL) separated from rat plasma (n-LDL, 100 microg/ml) or rat LDL modified either by activated rat polymorphonuclear leucocytes (pmn-LDL...

journal_title：Atherosclerosis

authors： Görög P

更新日期：1997-02-28 00:00:00

abstract：:The ability of triglyceride (TG)-rich lipoproteins from apolipoprotein (apo) E2 heterozygote, apo E3/2 which is relatively common, to stimulate cholesteryl ester synthesis in human monocyte-derived macrophages was studied to clarify the atherogenicity of apo E3/2. Twenty-three subjects were randomly sampled from our h...

journal_title：Atherosclerosis

authors： Saito M,Eto M,Makino I

更新日期：1997-02-28 00:00:00

abstract：:The aim of this study was to evaluate the cholesterol-lowering and antiatherosclerotic effect of the HMG-CoA reductase inhibitor pravastatin sodium at a dosage comparable to human therapy. Twelve heterozygous WHHL rabbits (13 months old) were fed 100 g per day of a low cholesterol (0.03%) enriched diet for 12 months. ...

journal_title：Atherosclerosis

authors： Harsch M,Braesen JH,Niendorf A

更新日期：1997-02-10 00:00:00

abstract：:Elevated serum ferritin concentrations between 200 and 500 microg/l have been found to be a strong risk factor for acute myocardial infarction in Finnish men, but the reason for this association is still uncertain. In the Finnish population ferritin concentrations correlated with factors of insulin resistance syndrome...

journal_title：Atherosclerosis

authors： Halle M,König D,Berg A,Keul J,Baumstark MW

更新日期：1997-02-10 00:00:00

abstract：:Using a simple, standardized denaturing gradient gel electrophoresis (DGGE) based mutation screening technique, a novel G-to-A mutation in the last base of the intron 12 splice acceptor site of the LDL receptor gene was found in 2 Danish families with familial hypercholesterolemia (FH). The mutation is shown to result...

journal_title：Atherosclerosis

authors： Nissen H,Hansen AB,Guldberg P,Petersen NE,Hansen TS,Hørder M

更新日期：1997-01-03 00:00:00

abstract：:The effect of the apolipoprotein C-II/C-III1 ratio on the capacity of purified bovine milk lipoprotein lipase to hydrolyse triglycerides was measured in a controlled model of pyrene-labeled nonanoyltriglycerides (1-2 ditetradecyl 3-pyrene nonanoyl glyceride) monolayer vesicles. Monolayer was composed of triglycerides,...

journal_title：Atherosclerosis

authors： Lambert DA,Catapano AL,Smith LC,Sparrow JT,Gotto AM Jr

更新日期：1996-12-20 00:00:00

abstract：:Copper mediated oxidative modification of high density lipoprotein (HDL) diminishes its capacity to promote cholesterol efflux from cells in culture. In the present study, HDL was isolated from eight subjects before and after a 10 day administration of the antioxidant vitamins C and E. After incubation HDL (1.25 mg pr...

journal_title：Atherosclerosis

authors： Rifici VA,Khachadurian AK

更新日期：1996-11-15 00:00:00

abstract：:To determine whether a relationship between echographically assessed carotid artery and left ventricular (LV) structures existed in asymptomatic men at risk for cardiovascular disease, we evaluated carotid and LV parameters in 69 subjects (23-62 years) without LV hypertrophy. The right common carotid far wall intima-m...

journal_title：Atherosclerosis

authors： Linhart A,Gariepy J,Giral P,Levenson J,Simon A

更新日期：1996-11-15 00:00:00

abstract：:Lipoprotein measurements in a group of 29 patients with massive proteinuria and without hypoalbuminemia, were compared with those observed in matched controls and patients with overt nephrotic syndrome to assess the influence of plasma albumin concentration and proteinuria in modulating blood lipid levels. Plasma apop...

journal_title：Atherosclerosis

authors： Joven J,Espinel E,Simó JM,Vilella E,Camps J,Oliver A

更新日期：1996-10-25 00:00:00

abstract：:Chylomicron catabolism in the bloodstream consists of lipolysis by lipoprotein lipase and uptake of remnants by the liver. In rats, triglyceride-rich emulsions can mimic chylomicron metabolism. To further validate this model in man, the emulsion was injected intravenously into fasting and into subjects previously fed ...

journal_title：Atherosclerosis

authors： Maranhão RC,Feres MC,Martins MT,Mesquita CH,Toffoletto O,Vinagre CG,Gianinni SD,Pileggi F

更新日期：1996-09-27 00:00:00

abstract：:Seasonal variation in the plasma lipids and lipoproteins is reported in the literature. Whether this variation is the result of changes in diet or other factors has not been adequately addressed. We investigated the effects of a controlled diet on the seasonal variation in the levels of plasma lipids and apolipoprotei...

journal_title：Atherosclerosis

authors： Mustad V,Derr J,Reddy CC,Pearson TA,Kris-Etherton PM

更新日期：1996-09-27 00:00:00

abstract：:The well established 'systemic' risk factors for atherosclerosis can explain only half of the variability in its occurrence. To account for some of the remaining variability, it was suggested that certain geometric features of atherosclerosis-prone segments ('geometric risk factors') can increase the likelihood of dis...

journal_title：Atherosclerosis

authors： Friedman MH,Baker PB,Ding Z,Kuban BD

更新日期：1996-09-06 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is known to be a secretory product of activated macrophages. TNF-alpha activates endothelial cells, stimulates angiogenesis and induces proliferation of smooth muscle cells (SMCs). Therefore, TNF-alpha has been suggested to be actively involved in the inflammatory events associa...

journal_title：Atherosclerosis

authors： Lei X,Buja LM

更新日期：1996-08-23 00:00:00

abstract：:In previous works, it has been evidenced that lipoperoxidative injury to macrophages caused by oxidatively modified low-density lipoprotein (O-LDL) plays an important role in foam cell formation, and that PSK, a protein bound polysaccharide extracted from the class Basidiomycetes Coriolus Versicolor, can protect macro...

journal_title：Atherosclerosis

authors： Yuan C,Mei Z,Liu S,Yi L

更新日期：1996-08-02 00:00:00

abstract：:Over 200 risk factors for cardiovascular disease (CVD) have now been identified. Among these, the three most important are (1) abnormal lipids, including the fact that there are more than 15 types of cholesterol-containing lipoproteins and four different types of triglyceride-rich particles, some of which are very ath...

journal_title：Atherosclerosis

authors： Castelli WP

更新日期：1996-07-01 00:00:00

abstract：:Ciprofibrate is an effective treatment for three main types of atherogenic hyperlipoproteinaemia: type IIa hypercholesterolaemia, type IIb combined hyperlipidaemia, and type IV hypertriglyceridaemia. In type IIa hypercholesterolaemia, administration of 100 mg/day of ciprofibrate, to approximately 3000 patients, decrea...

journal_title：Atherosclerosis

authors： Turpin G,Bruckert E

更新日期：1996-07-01 00:00:00

abstract：:In order to obtain information about the developmental mechanisms of restenosis after angioplasty, we investigated an association between the expression of platelet-derived growth factors (PDGFs) and neointimal cell accumulation in rabbit femoral arteries subjected to balloon angioplasty. Northern analysis demonstrate...

journal_title：Atherosclerosis

authors： Uchida K,Sasahara M,Morigami N,Hazama F,Kinoshita M

更新日期：1996-07-01 00:00:00

abstract：:We describe a new method for the rapid fractionation of plasma lipoproteins, which makes use of a new non-ionic, iodinated, density gradient medium, iodixanol, commercially available as Optiprep(TM). The method is simple: plasma or serum is mixed with iodixanol followed by centrifugation in a vertical or near vertical...

journal_title：Atherosclerosis

authors： Graham JM,Higgins JA,Gillott T,Taylor T,Wilkinson J,Ford T,Billington D

更新日期：1996-07-01 00:00:00

abstract：:Cholesteryl esters (CE) exchange between lipoproteins through the action of cholesteryl ester transfer protein (CETP). Situations at high risk for atherosclerosis are often accompanied by an accelerated net mass CE transfer (CET) from high density lipoproteins (HDL) to very low (VLDL) and low density lipoproteins (LDL...

journal_title：Atherosclerosis

authors： Elchebly M,Porokhov B,Pulcini T,Berthezène F,Ponsin G

更新日期：1996-06-01 00:00:00

abstract：:Limited data are available on the determinants of homocysteinemia or the association between plasma homocysteine (Hcy) levels and prevalent cardiovascular disease (CVD) in maintenance dialysis patients. We assessed etiology of renal failure, residual renal function and dialysis adequacy-related variables, and vitamin ...

journal_title：Atherosclerosis

authors： Bostom AG,Shemin D,Lapane KL,Nadeau MR,Sutherland P,Chan J,Rozen R,Yoburn D,Jacques PF,Selhub J,Rosenberg IH

更新日期：1996-06-01 00:00:00

abstract：:In response to homocysteine induced toxicity in human umbilical vein endothelial cells, minimal changes in the concentration of cellular protein thiols but substantial changes in the concentration of intracellular soluble thiols were observed. The latter correlated closely with changes in cellular glutathione levels. ...

journal_title：Atherosclerosis

authors： Blundell G,Jones BG,Rose FA,Tudball N

更新日期：1996-05-01 00:00:00

abstract：:In the process of screening apolipoprotein (apo) E genotypes in a population of subjects with lipid abnormalities, we have identified five subjects (one homozygote and four heterozygotes) with an abnormal 109 base pairs band following apo E restriction isotyping of amplified DNA with the restriction endonuclease CfoI....

journal_title：Atherosclerosis

authors： Pocovi M,Cenarro A,Civeira F,Myers RH,Casao E,Esteban M,Ordovas JM

更新日期：1996-04-26 00:00:00

abstract：:To investigate possible relationships between plasma low density lipoprotein (LDL) cholesterol and fasting plasma insulin in the elderly, cross-sectional random samples of age cohorts (65, 75, 80 and 85 years, n = 1188, M/F 38/62 percent) were studied in the neighbouring cities of Helsinki and Vantaa, Finland. Plasma ...

journal_title：Atherosclerosis

authors： Strandberg TE,Tilvis RS,Lindberg O,Valvanne J,Sairanen S,Ehnholm C,Tuomilehto J

更新日期：1996-04-05 00:00:00

abstract：:We have compared the uptake of desialylated low density lipoprotein (LDL) with other modified forms of LDL in mouse peritoneal macrophages and PMA-activated human U937 monocytes. Neuraminidase-treated LDL (NT-LDL) caused significant cholesterol ester accumulation in both cell types, although the efficiency relative to...

journal_title：Atherosclerosis

authors： Grewal T,Bartlett A,Burgess JW,Packer NH,Stanley KK

更新日期：1996-03-01 00:00:00

abstract：:Earlier we have shown a significant positive association between muscle fiber distribution, i.e. percentage of slow-twitch (ST) fibers in the vastus lateralis muscle, and serum high-density lipoprotein cholesterol (HDL-C) level. This association may be due to the fact that ST fibers have a high capacity for oxidative ...

journal_title：Atherosclerosis

authors： Tikkanen HO,Näveri H,Härkönen M

更新日期：1996-02-01 00:00:00

abstract：:Methylamine can be converted by semicarbazide-sensitive amine oxidase (SSAO) to formaldehyde and hydrogen peroxide, which have been proven to be toxic towards cultured endothelial cells. We investigated whether or not these deaminated products from methylamine can exert potentially hazardous toxic effects in vivo. Lon...

journal_title：Atherosclerosis

authors： Yu PH,Zuo DM

更新日期：1996-02-01 00:00:00

abstract：:The potential interest of serum elastase activity (SEA) as a marker of vascular aging and atherosclerosis was studied as part of an epidemiological study on vascular and cognitive aging (EVA Study). SEA was measured in 555 men and 774 women aged 59-71 years with a synthetic substrate, suc(ala)3pNA, according to a modi...

journal_title：Atherosclerosis

authors： Bizbiz L,Bonithon-Kopp C,Ducimetierè P,Berr C,Alperovitch A,Robert L

更新日期：1996-02-01 00:00:00

abstract：:To assess the risk for homocyst(e)ine-associated vascular disease, overt hyperhomocyst(e)inemia should be demonstrated. In nonhomocystinuric subjects, clinical vascular disease must have developed after 40 or more years of persistent hyperhomocyst(e)inemia which may not be present without a genetic defect(s). Nongenet...

journal_title：Atherosclerosis

authors： Kang SS,Wong PW

更新日期：1996-01-26 00:00:00

abstract：:The relative importance of reduced plasma high density lipoprotein-cholesterol (HDL-C) levels and elevated plasma triglyceride (TG) concentrations as risk factors for ischemic heart disease (IHD) was examined in a sample of 2177 men from the Québec City suburbs. The sample included 202 men with known IHD. The relation...

journal_title：Atherosclerosis

authors： Lamarche B,Després JP,Moorjani S,Cantin B,Dagenais GR,Lupien PJ

更新日期：1996-01-26 00:00:00

abstract：:We have examined the prevalence of clinically significant atherosclerosis in 78 patients with type III hyperlipoproteinemia (HLP) and homozygosity for apolipoprotein (apo) E2. Forty-six of these individuals (59%) had no atherosclerosis, 32 patients (41%) had atherosclerosis, i.e., atherosclerosis of the extracranial c...

journal_title：Atherosclerosis

authors： Dobmeyer J,Lohrmann J,Feussner G

更新日期：1996-01-05 00:00:00

abstract：:A protective effect of estrogen is the most obvious reason for the substantial and consistent favored status of women vs. men with regard to coronary heart disease (CHD). This paper briefly reviews the history of studies of the estrogen-heart disease hypothesis, the reason why clinical trials of postmenopausal estroge...

journal_title：Atherosclerosis

authors： Barrett-Connor E

更新日期：1995-12-01 00:00:00

abstract：:Quantitative assessment of atherosclerosis during its natural history and following therapeutic interventions is important, as cardiovascular disease remains the most significant cause of morbidity and mortality in industrial societies. While coronary angiography delineates the vessel lumen, permitting only the indire...

journal_title：Atherosclerosis

authors： von Birgelen C,Slager CJ,Di Mario C,de Feyter PJ,Serruys PW

更新日期：1995-12-01 00:00:00

abstract：:Patients with homozygous familial hypercholesterolemia (FH), as a result of the increased levels and prolonged residence time of low density lipoprotein (LDL) in plasma, have a strong tendency toward accumulation of LDL-cholesterol in the arterial wall, causing premature atherosclerosis. This phenomenon may enhance pe...

journal_title：Atherosclerosis

authors： Napoli C,Postiglione A,Triggiani M,Corso G,Palumbo G,Carbone V,Ruocco A,Ambrosio G,Montefusco S,Malorni A,Condorelli M,Chiariello M

更新日期：1995-12-01 00:00:00

abstract：:Apolipoprotein B-100 (apo B-100) is the protein component of low density lipoprotein (LDL) responsible for its binding and clearance by LDL receptors (LDL-R). In familial defective apo B-100 (FDB), a mutation in apo B-100 at residue 3500 markedly reduces its affinity for LDL-R, often causing accumulation of defective ...

journal_title：Atherosclerosis

authors： Maher VM,Gallagher JJ,Thompson GR,Myant NB

更新日期：1995-11-01 00:00:00

abstract：:In this study, lipid peroxides in plasma and the low density lipoprotein (LDL) fraction and plasma concentrations of vitamin E, lipids and lipoproteins were measured in 22 smokers (mean age 35 years), 26 non-smoking patients with peripheral vascular disease (PVD), mean age 66 years), and 23 younger (ages < or = 55 yea...

journal_title：Atherosclerosis

authors： Sanderson KJ,van Rij AM,Wade CR,Sutherland WH

更新日期：1995-11-01 00:00:00